Interventional Orthopedics Foundation Annual Meeting. In Vitro Evaluation of Injectable, Placental Tissue-Derived Products for Interventional Orthopedics. However, that data is available for the Regenexx procedure. However, regrettably, for most of what’s being offered as “stem cell therapy,” there isn’t much published data that allows us to really answer this question. The upshot? Answering the question of how long does stem cell therapy last for knees takes some research. The answer is 5-7 years in about two-thirds of the patients. No one else has published or posted on-line data that would allow us to answer that question. In summary, the type of long-term data that can answer the question “how long does stem cell therapy last for knees” only exists for the Regenexx bone marrow based procedure. In reviewing this data farther out (not shown), patients that respond can get up to 5-7 years of relief from a single treatment. You can see here below that these patients do well for four years, as higher is better in this graph. This is when patients who are routinely treated for knee arthritis get sent questionnaires to fill out at set time points. We can also look at registry results for Regenexx. Hence, you can clearly see that in most patients, the positive effect of much-improved function lasts for at least two years, which is all this particular study covered. This KSS score looks at things like the range of motion of the knee and the ability to walk and climb stairs:įirst, in looking at that published data, 69% of the patients had achieved success with their knees by two years out. A higher number here represents better function on this Knee Society Score metric. This takes patients to two years and compares that outcome versus physical therapy (which only lasted 3-months). Below is a graph from our randomized controlled trial (Regenexx procedure) on the use of bone marrow concentrate (a same day stem cell procedure) to treat knee arthritis patients (5). To keep this simple, we’ll focus on the outcomes for patients with knee arthritis. Let’s dig into the data to answer this question for bone marrow since that’s the only data that exists. Amniotic/umbilical cord products and exosomes have a very long way to go to answer this question. Fat based knee treatments will begin to get there in the next few years. Right now, only the research on bone marrow stem cells is robust enough to reliably answer the question of how long does stem cell therapy last for knees. How Long Does Stem Cell Therapy Last for Knees? If you want to learn more about these topics, read my mini-book on how to pick a reputable stem cell clinic for your knees: Again, there is very little research in real patients that shows that exosomes will be effective at helping your knees. Exosomes – These are tiny packets of cell to cell communications that have just begun to be used to treat knee arthritis.Regrettably, almost all of that research uses different cells than those used by clinics and it’s almost all in animals and not humans. This may also come as a surprise as someone told you that there was extensive research on this type of therapy. In addition, there is no or very little research in real patients that shows either will be effective at helping your knees. While this may come as a surprise as someone told you that this was a type of stem cell procedure that had millions of young cells, regrettably, this was a sales pitch without much reality. Amniotic or umbilical cord cells – First, these products are derived from live births and extensive research by third parties and universities has shown that these products have no living stem cells (1-3).A commonly used procedure here is called Lipogems. However, the stem cells may still exert effects to help heal cartilage. Fat – this isn’t really a stem cell procedure because it’s not legal to separate the stem cells from the fat.We are reviewing data here for the Regenexx-SD procedure with is high-dose bone marrow concentrate. This is often called BMC or BMAC (Bone Marrow Aspirate Concentrate). Bone marrow concentrate – this is when the doctor takes your bone marrow aspirate and centrifuges it to concentrate the stem cell fraction.More Research that Shows this Approach Works in Patients with Knee Problems We can break down what we know on each stem cell type being offered: In order to answer the question, “How long does stem cell therapy last for knees?”, we need long-term research on patients that have been followed for many years. There are a few options on which research exists and some options where no or very little research exists (4). Find a Location What are the Different Stem Cell Types that are Used? 94 clinic locations offering non-surgical Regenexx solutions for musculoskeletal pain.
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